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Glossary CKD c hronic kidney disease CNS central nervous system CVD cardiovascular disease FDA Food and Drug Administration GLP-1 glucagon-like peptide-1 GLP-1s glucagon-like peptide-1 receptor agonists HF h eart failure MASH metabolic dysfunction-associated steatohepatitis OA osteoarthritis OSA obstructive sleep apnea PAD peripheral arterial disease SC subcutaneous T2DM type 2 diabetes mellitus U.S

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The dosage that led to these symptoms was 1.0 to 1.4 mg/kg in an infant aged 6 to 8 weeks

We measure clinical effectiveness using the Number Needed to Treat (NNT) - how many patients you have to treat for one to achieve a meaningful (50%) reduction in pain